Publications

2018 & 2019 (selected)

Wallace, Taylor C., Scott Bultman, Chris D’Adamo, Carrie R. Daniel, Justine Debelius, Emily Ho, Heather Eliassen, et al. 2019. “Personalized Nutrition in Disrupting Cancer – Proceedings From the 2017 American College of Nutrition Annual Meeting.” Journal of the American College of Nutrition 38 (1): 1–14.

Chinopoulos, Christos, and Thomas N. Seyfried. “Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis.” ASN Neuro, Jan. 2018, doi:10.1177/1759091418818261.

Elsakka, Ahmed M. A., Mohamed Abdel Bary, Eman Abdelzaher, Mostafa Elnaggar, Miriam Kalamian, Purna Mukherjee, and Thomas N. Seyfried. 2018. “Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up.” Frontiers in Nutrition 5: 20.

Google Scholar: Thomas Seyfried Profile Page

PubMed: Seyfried TN

• Taus LJ, Flores RE, Seyfried TN.  Quantification of metastatic load in a syngeneic murine model of metastasis. Cancer Lett. 2017 Oct 1;405:56-62. doi: 10.1016/j.canlet. 2017.07.011.
• Klement RJ, Feinman RD, Gross EC, Champ CE, D’Agostino DP, Fine EJ, Kämmerer U, Poff A, Rho JM, Seyfried TN, Scheck AC. Need for new review of article on ketogenic dietary regimes for cancer patients. Med Oncol. 2017 Jun;34(6):108. doi: 10.1007/s12032-017-0968-4.
• Arismendi-Morillo G, Castellano-Ramírez A,  Seyfried TN. Ultrastruct Pathol. 2017 May-Jun;41(3):234-244. doi: Ultrastructural characterization of the Mitochondria-associated membranes abnormalities in human astrocytomas: Functional and therapeutics implications.10.1080/01913123.2017.1300618.
• Puchowicz MA, Seyfried TN. Novel ketone body therapy for managing Alzheimer’s disease: An Editorial Highlight for Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer’s disease. J Neurochem. 2017 Apr;141(2):162-164. doi: 10.1111/jnc.
• Seyfried TN, Yu G, Maroon JC, D’Agostino DP. Press-pulse: a novel therapeutic strategy for the metabolic management of cancer. Nutr Metab (Lond). 2017 Feb 23;14:19. doi: 10.1186/s12986-017-0178-2. eCollection 2017. PMID: 28250801
• Chen E, Kiebish MA, McDaniel J, Gao F, Narain NR, Sarangarajan R, Kacso G, Ravasz D, Seyfried TN, Adam-Vizi V, Chinopoulos C. The total and mitochondrial lipidome of Artemia franciscana encysted embryos. Biochim Biophys Acta. 2016 Nov;1861(11):1727-1735. doi: 10.1016/j.bbalip.2016.08.007.
• Schneider JS, Seyfried TN, Choi HS, Kidd SK. Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson’s Disease. PLoS One. 2015 Dec 2;10(12):e0143351. doi: 10.1371/journal.pone.0143351
• Ta NL, Seyfried TN. Influence of Serum and Hypoxia on Incorporation of [(14)C]-D-Glucose or [(14)C]-L-Glutamine into Lipids and Lactate in Murine Glioblastoma Cells. Lipids. 2015 Dec;50(12):1167-84.
• Seyfried TN. Cancer as a mitochondrial metabolic disease. Front Cell Dev Biol. 2015 Jul 7;3:43.
• Akgoc Z, Iosim S, Seyfried TN. Bis(monoacylglycero)phosphate as a Macrophage Enriched Phospholipid. Lipids. 2015 Sep;50(9):907-12.
• Poff AM, Ward N, Seyfried TN, Arnold P, D’Agostino DP. Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy. PLoS One. 2015 Jun 10;10(6):e0127407.
• Maroon JC, Seyfried TN, Donohue JP, Bost J. The role of metabolic therapy in treating glioblastoma multiforme. Surg Neurol Int. 2015 Apr 16;6:61.
• Rockwell HE, McCurdy VJ, Eaton SC, Wilson DU, Johnson AK, Randle AN, Bradbury AM, Gray-Edwards HL, Baker HJ, Hudson JA, Cox NR, Sena-Esteves M, Seyfried TN, Martin DR. AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. ASN Neuro. 2015 Apr 13;7(2).
• Meidenbauer JJ, Mukherjee P, Seyfried TN. nThe glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr Metab (Lond). 2015 Mar
• Akgoc Z, Sena-Esteves M, Martin DR, Han X, d’Azzo A, Seyfried TN. Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses. J Lipid Res. 2015 May;56(5):1006-13.
• Heinecke KA, Luoma A, d’Azzo A, Kirschner DA, Seyfried TN.
• Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis. ASN Neuro. 2015 Feb 18;7(1).
• McCurdy VJ, Rockwell HE, Arthur JR, Bradbury AM, Johnson AK, Randle AN, Brunson BL, Hwang M, Gray-Edwards HL, Morrison NE, Johnson JA, Baker HJ, Cox NR, Seyfried TN, Sena-Esteves M, Martin DR. Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. Gene Ther. 2015 Feb;22(2):181-9.
• Maroon JC, Seyfried TN, Donohue JP, Bost J. The role of metabolic therapy in treating glioblastoma multiforme. Surg Neurol Int. 2015 Apr 16;6:61.
• Rockwell HE, McCurdy VJ, Eaton SC, Wilson DU, Johnson AK, Randle AN, Bradbury AM, Gray-Edwards HL, Baker HJ, Hudson JA, Cox NR, Sena-Esteves M, Seyfried TN, Martin DR. AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. ASN Neuro. 2015 Apr 13;7(2).
• Meidenbauer JJ, Mukherjee P, Seyfried TN. The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr Metab (Lond). 2015 Mar 11;12:12.
• Akgoc Z, Sena-Esteves M, Martin DR, Han X, d’Azzo A, Seyfried TN. Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses.
• J Lipid Res. 2015 May;56(5):1006-13.
• Heinecke KA, Luoma A, d’Azzo A, Kirschner DA, Seyfried TN. Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis. ASN Neuro. 2015 Feb 18;7(1).
• McCurdy VJ, Rockwell HE, Arthur JR, Bradbury AM, Johnson AK, Randle AN, Brunson BL, Hwang M, Gray-Edwards HL, Morrison NE, Johnson JA, Baker HJ, Cox NR, Seyfried TN, Sena-Esteves M, Martin DR. Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. Gene Ther. 2015 Feb;22(2):181-9.
• Seyfried TN, Flores R, Poff AM, D’Agostino DP, Mukherjee P. Metabolic therapy: a new paradigm for managing malignant brain cancer. Cancer Lett. 2015 Jan 28;356(2 Pt A):289-300.
• Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16647-53.
• Seyfried TN, Rockwell HE, Heinecke KA, Martin DR, Sena-Esteves M. Ganglioside storage diseases: on the road to management. Adv Neurobiol. 2014; 9:485-99.
• Seyfried TN. Ketone strong: emerging evidence for a therapeutic role of ketone bodies in neurological and neurodegenerative diseases.
• J Lipid Res. 2014 Sep; 55(9): 1815-7.
• Mantis JG, Meidenbauer JJ, Zimick NC, Centeno NA, Seyfried TN. Glucose reduces the anticonvulsant effects of the ketogenic diet in EL mice.
• Epilepsy Res. 2014 Sep; 108(7): 1137-44.
• Meidenbauer JJ, Ta N, Seyfried TN. Influence of a ketogenic diet, fish-oil, and calorie restriction on plasma metabolites and lipids in C57BL/6J mice.
• Nutr Metab (Lond). 2014 May 22; 11:23.
• Poff AM, Ari C, Arnold P, Seyfried TN, D’Agostino DP. Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer.n Int J Cancer. 2014 Oct 1;135(7):1711-20.
• Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, Scott DA, Richardson AD, Seyfried TN, Chiles TC. Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem. 2014 Mar 7;289(10):7011-24.
• Seyfried TN, Flores RE, Poff AM, D’Agostino DP. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 2014 Mar;35(3):515-27.
• Ta NL, Jia X, Kiebish M, Seyfried TN. Autosomal dominant inheritance of brain cardiolipin fatty acid abnormality in VM/DK mice: association with hypoxic-induced cognitive insensitivity. Lipids. 2014 Jan;49(1):113-7.
• Ahmed SS, Li H, Cao C, Sikoglu EM, Denninger AR, Su Q, Eaton S, Liso Navarro AA, Xie J, Szucs S, Zhang H, Moore C, Kirschner DA, Seyfried TN, Flotte TR, Matalon R, Gao G. A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice.
• Mol Ther. 2013 Dec;21(12):2136-47.
• Poff AM, Ari C, Seyfried TN, D’Agostino DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer.
• PLoS One. 2013 Jun 5;8(6):e65522.
• Bradbury AM, Cochran JN, McCurdy VJ, Johnson AK, Brunson BL, Gray-Edwards H, Leroy SG, Hwang M, Randle AN, Jackson LS, Morrison NE, Baek RC, Seyfried TN, Cheng SH, Cox NR, Baker HJ, Cachón-González MB, Cox TM, Sena-Esteves M, Martin DR. Therapeutic response in feline sandhoff disease despite immunity to intracranial gene therapy. Mol Ther. 2013 Jul;21(7):1306-15.
• Arthur JR, Wilson MW, Larsen SD, Rockwell HE, Shayman JA, Seyfried TN. Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice. Neurochem Res. 2013 Apr;38(4):866-75.